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When taken by mouth in an immediate-release formulation, the onset of pain relief usually occurs within an hour. It is often combined with paracetamol (acetaminophen) as this is known to improve the efficacy of tramadol in relieving pain. Tramadol is used to treat both acute and chronic pain of moderate to (moderately) severe intensity.
Tramadol monotherapy does not usually provide adequate analgesia. In chronic non-cancer pain, there is little evidence for the use of tramadol for more than three months. Tramadol is considered to be a relatively safe analgesic.
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The tolerability of ULTRAM® can be improved by initiating therapy with the following titration regimen as advised by Wikipedia ULTRAM® should be started at 25 mg/day QAM and titrated in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg q.i.d.).
Thereafter the total daily dose may be increased by 50 mg as tolerated every 3 20 days to reach 200 mg/day (50 mg q.i.d.). After titration, ULTRAM® 50 to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day
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You should not drive, use heavy machinery, or perform any dangerous activities until you know how this drug affects you. Tramadol may also cause other side effects.
The more common side effects of tramadol can include:
- nausea and vomiting
- lack of energy
- dry mouth
ULTRAM should not be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product, or opioids.
ULTRAM is contraindicated in any situation where opioids are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics, opioids, or psychotropic drugs.
ULTR AM® may worsen the central nervous system and respiratory depression in these patients.